Blood Lines
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A view into the souls of HIV+ youth Produced & Directed by: Rebecca Guberman & Jennifer Jako

New updated 2015 version now available

The New York Times calls Blood Lines "a pointed, moving documentary" and "an eloquent plea for understanding"
Breast cancer cells. Here, we studied the fgf-8-activated signalling pathways mediating tsp-1 repression in s115 cells and in non-tumorigenic mcf10a cells. Inhibition of fgf receptors or of mek1/2 and pi3k with specific inhibitors (pd173074, u0126 or ly294002, respectively) restored tsp-1 mrna expression in the presence of fgf-8 in s115 cells. Furthermore, u0126 and ly294002 increased tsp-1 mrna expression in s115 cells over-expressing fgf-8. will generic viagra available us real viagra pills viagra 20 mg prescription In mcf10a cells, fgf-8 treatment also decreased tsp-1 expression and the effect was dependent on active mek1/2. In conclusion, fgf-8 suppresses tsp-1 expression through two independent pathways, mek1/2 and pi3k. Repression of tsp-1 may be an important mechanism involved in induction of an angiogenic phenotype and growth of fgf-8-expressing breast cancer. Pmid: 20370578 [pubmed - indexed for medline] publication types, mesh terms, substances publication types research support, non-u. S. Gov't mesh terms angiogenesis modulating agents/metabolism animals blotting, western breast neoplasms butadienes/pharmacology cell line cell line, tumor chromones/pharmacology down-regulation/drug effects enzyme inhibitors/pharmacology extracellular signal-regulated map kinases/metabolism female fibroblast growth factor 8/genetics fibroblast growth factor 8/metabolism* fibroblast growth factor 8/pharmacology gene expression humans map kinase kinase 1/metabolism* map kinase kinase 2/metabolism* map kinase signaling system mice mitogen-activated protein kinases/metabolism morpholines/pharmacology nitriles/pharmacology phosphatidylinositol 3-kinases/metabolism* polymerase chain reaction pyrimidines/pharmacology recombinant proteins/metabolism recombinant proteins/pharmacology signal transduction* thrombospondin 1/metabolism* substances angiogenesis modulating agents butadienes chromones enzyme inhibitors morpholines nitriles pd 173074 pyrimidines recombinant proteins thrombospondin 1 u 0126 fibroblast growth factor 8 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one map2k2 protein, mouse phosphatidylinositol 3-kinases extracellular signal-regulated map kinases mitogen-activated protein kinases map kinase kinase 1 map kinase kinase 2 linkout - more resources full text sources informa healthcare ebsco ingenta plc other literature sources labome researcher resource - exactantigen/labome medical map2k1 gene - genetics home reference miscellaneous swets information services supplemental content save items add to favorites loading related citations in pubmed inhibition of either phosphatidylinositol 3-kinase/akt or the mitogen/extracellular-regulated kinase, mek/erk, signaling pathways suppress growth of breast cancer cell lines, but mek/erk signaling is critical for cell survival. [breast cancer res treat. 2005] inhibition of either phosphatidylinositol 3-kinase/akt.
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