Blood Lines
synopsis Tions (639 mutated alleles) are included in the locus-specific database (www. Humgen. Rwth-aachen. De). Except for a few population-specific founder alleles and the common c. 107c>t (p. Thr36met) missense change, pkhd1 is characterized by significant allelic diversity, making mutation screening time-consuming and labor-intensive. Mutations are distributed throughout the gene's coding sequence; however, they are not equally scattered. Thus, we aimed to set up an algorithm for efficient molecular genetic diagnostics in arpkd. A total of 80% of known pkhd1 mutations can be identified if a subset of 27 out of 77 dhplc fragments is screened. The current study provides an essential platform for pkhd1 mutation screening in a routine setting that will largely alleviate molecular genetic diagnostics in patients suspected to have arpkd. (c) 2005 wiley-liss, inc. Pmid: 15706593 [pubmed - indexed for medline] publication types, mesh terms, substances publication types research support, non-u. S. Gov't review mesh terms algorithms alleles chromatography, high pressure liquid cohort studies dna mutational analysis/methods* databases, factual european continental ancestry group/genetics genes, recessive genetic testing/methods* haplotypes/genetics humans open reading frames/genetics polycystic kidney, autosomal recessive/genetics* receptors, cell surface/genetics* sensitivity and specificity substances pkhd1 protein, human receptors, cell surface linkout - more resources full text sources john wiley & sons, inc. Ebsco ohiolink electronic journal center proquest information and learning other literature sources cos scholar universe labome researcher resource - exactantigen/labome medical autosomal recessive polycystic kidney diseasee - genetic alliance pkhd1 gene - genetics home reference polycystic kidney disease - genetics home reference genetic testing - medlineplus health information kidney cysts - medlineplus health information miscellaneous swets information services supplemental content save items add to favorites loading related citations in pubmed review pkhd1 m. viagra for sale cheap generic viagra cheap viagra online cheap viagra online viagra without a doctor prescription viagra online
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A view into the souls of HIV+ youth Produced & Directed by: Rebecca Guberman & Jennifer Jako

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The New York Times calls Blood Lines "a pointed, moving documentary" and "an eloquent plea for understanding"
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