Blood Lines
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Calendar directory employment donate monday, october 8, 2012 the laboratory of molecular neuro-oncology overview introduction in the news neuronal rna binding proteins nova fmrp hu brptb clip paraneoplastic neurologic degeneration introduction current pnd research clinical studies clinical trials open for enrollment methods/new research clip method nova clip targets preparation of brain polyribosomes splicing chip forum lab members publications contact internal lab page (password required) paraneoplastic neurologic degeneration the paraneoplastic neurologic disorders (pnds) are a set of neurodegenerative disorders that arise in the setting of cancer and are believed to be immune mediated (reviewed in darnell rb and posner jb. N engl j med, 349:1543-1554, 2003 and darnell rb. Arch neurol, 61:30-32; 2004). Pnd patients harbor high titer autoantibodies targeted to specific tumor and neuronal antigens (termed onconeural antigens). We have used pnd antisera to clone and characterize the target antigens. The significance of the pnds is several-fold. The disorders are associated with tumor immune responses that are effective, as well as autoimmune neurologic disease, both issues of major clinical importance. viagra for sale cheap viagra online buy viagra cheap viagra pills online cheap viagra buy cheap viagra cheap viagra viagra for sale viagra online In addition, it is believed that the onconeural antigens are immunogenic in part because of their tissue restriction-the proteins appear to be expressed normally only in immune privileged neurons (and in some instances testes), and abnormally in specific types of tumor cells. The study of their biology is relevant to the areas of neuroscience (musunuru k and darnell rb. Annu rev neurosci, 24:239-62, 2001) and cancer biology (albert ml and darnell rb. Nature rev cancer, 4:36-44, 2004). We are actively studying the biology of two pnd antigens that are neuron-specific rna binding proteins, the nova and hu antigens. The rockefeller university | 1230 york avenue, new york, ny 10065 | 212-327-8000 copyright © 2004–2012 the rockefeller university. All rights reserved. Contact | comments | site map | copyright complaints. Romes paraneoplastic peripheral neuropathies further readings [intro] approach to the patient paraneoplastic neurologic disorders specific paraneoplastic neurologic syndromes paraneoplastic encephalomyelitis and focal encephalitis encephalitides with antibodies to cell surface or synaptic proteins table 101 3 paraneop.
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A view into the souls of HIV+ youth Produced & Directed by: Rebecca Guberman & Jennifer Jako

New updated 2015 version now available

The New York Times calls Blood Lines "a pointed, moving documentary" and "an eloquent plea for understanding"
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